Multisystem Inflammatory Syndrome in Children (MISC-C) formerly referred to as pediatric inflammatory multisystem syndrome (PIMS) is a recently defined condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs.

The incidence is rare and we do not yet know exactly what causes MIS-C, they are many doctors working diligently to get answers. However, we know that many children with MIS-C have evidence of previous or current infection with Covid-19 or had been around someone with COVID-19.

The CDC currently defines MISC-C by the following criteria:

  • An individual aged <21 years presenting with prolonged fever (temperature > 38.0C/100.4F for more than 24 hours)
  • laboratory evidence of inflammation
  • Evidence of clinically severe illness requiring hospitalization, with multisystem (>2) organ involvement (cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic, or neurological); AND
  • No alternative plausible diagnoses; AND
  • Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms

What are MIS-C symptoms?

It is important to remember that not all children show all the same symptoms on presentation

  • Fever
  • Abdominal pain
  • Vomiting
  • Diarrhea
  • Neck pain
  • Rash
  • Bloodshot eyes
  • Feeling extra tired
  • Swollen hands and feet which may also be red

It is important for parents to be informed. MIS-C is not contagious, but it can be serious, even deadly, thus far most children who were diagnosed with this condition have gotten better with medical care/treatment. If you are concerned your child may have MIS-C seek immediate medical attention/call your child’s physician to get them evaluated in person.

Seek emergency care right away if your child is showing any of these emergency warning signs of MIS-C or other concerning signs trouble breathing, pain or pressure in the chest that does not go away, new confusion, inability to wake or stay awake, bluish lips or face, severe abdominal pain.